Velké Žernoseky is a municipality and village in Litoměřice District in the Ústí nad Labem Region of the Czech Republic. It has about 500 inhabitants.

Velké Žernoseky is located about 4 kilometres (2 mi) west of Litoměřice and 14 km (9 mi) south of Ústí nad Labem. It lies in the Central Bohemian Uplands. The highest point is the hill Strážiště at 362 metres (1,188 ft) above sea level. The municipality is situated on the right bank of the Elbe River.

The first written mention of Velké Žernoseky is in the foundation deed of the Litoměřice Chapter from 1218.

Historical population

Year Pop. ±% 1869 457 —     1880 439 −3.9% 1890 421 −4.1% 1900 481 +14.3% 1910 633 +31.6%	Year Pop. ±% 1921 601 −5.1% 1930 705 +17.3% 1950 581 −17.6% 1961 642 +10.5% 1970 581 −9.5%	Year Pop. ±% 1980 546 −6.0% 1991 442 −19.0% 2001 472 +6.8% 2011 473 +0.2% 2021 480 +1.5%
Source: Censuses

Since the 12th century, Velké Žernoseky is known for viticulture. It belongs to the Litoměřická wine sub-region and is one of the northernmost wine-growing places in Europe.

Velké Žernoseky is located on the railway line Ústí nad Labem–Lysá nad Labem.

The Church of Saint Nicholas was built in the Gothic style in the 14th century and rebuilt in the 16th century.

Velké Žernoseky Castle is a simple Baroque castle in the centre of the village, built in the 17th century on the site of the former fortress. Today it is used as a winery and for accommodation.

• Official website