Velyka Lepetykha (Ukrainian: Велика Лепетиха; Russian: Большая Лепетиха) is a rural settlement in Kakhovka Raion, Kherson Oblast, southern Ukraine. It hosts the administration of Velyka Lepetykha settlement hromada, one of the hromadas of Ukraine. The settlement is located on the left bank of the Kakhovka Reservoir, an artificial reservoir on the Dnieper. It has a population of 7,707 (2022 estimate).

Until 18 July, 2020, Velyka Lepetykha was the administrative center of Velyka Lepetykha Raion. The raion was abolished in July 2020 as part of the administrative reform of Ukraine, which reduced the number of raions of Kherson Oblast to five. The area of Velyka Lepetykha Raion was merged into Kakhovka Raion.

Until 26 January 2024, Velyka Lepetykha was designated urban-type settlement. On this day, a new law entered into force which abolished this status, and Velyka Lepetykha became a rural settlement.

Velyka Lepetykha has access to a paved road which follows the left bank of the Dnieper and connects Kakhovka with Kamianka-Dniprovska. In Kakhovka, there is access to the Highway M14, connecting Kherson with Mariupol via Melitopol. Another road leads to Henichesk via Nyzhni Sirohozy.