Wassa Amenfi District is a former district that was located in Western Region, Ghana. Originally created as an ordinary district assembly in 1988, which was created from the former Aowin-Amenfi District Council. However, in August 2004, it was split off into two new districts: Wassa Amenfi West District (which it was elevated to municipal district assembly status on 15 March 2018; capital: Asankragua) and Wassa Amenfi East District (which it was also elevated to municipal district assembly status on 15 March 2018; capital: Wassa-Akropong). The district assembly was located in the central part of Western Region and had Asankragua as its capital town.

5°48′33.12″N 2°26′8.52″W / 5.8092000°N 2.4357000°W / 5.8092000; -2.4357000