Yautepec District is located in the east of the Sierra Sur Region of the State of Oaxaca, Mexico.

The district lies in the eastern end of the Sierra Madre del Sur and is mountainous, with an area of 4,772 square kilometers. The temperature is generally temperate, warmer in the lower areas and cooler higher up, with prevalent winds from the north. Trees include mahogany, cedar, oak, guanacaste and pine. Mango, tamarind, plum, sapodilla, lemon, avocado and papaya fruits are grown. Wild fauna include wild boar, ocelots, snakes, mountain lion, coyotes and foxes.

The total population is 31,688. Indigenous people include Zapotec, Mixe and Chontal. Economic activities include agriculture, growing maize, sorghum, peanuts, beans, coffee and various fruits. Some cattle is raised, and villagers often raise goats, sheep, and pigs. Hunting and fishing are typically practiced on a small scale for personal consumption. There is some logging activity, and the wild maguey is harvested for its juice.

The district includes the following municipalities, with population statistics as of 2005:

Municipality	Area km	Total Population	Indigenous Population
Asunción Tlacolulita	245	699	54
Nejapa de Madero	370	7,285	1,300
San Bartolo Yautepec	196	661	195
San Carlos Yautepec	2,492	9,857	3,781
San Juan Juquila Mixes	227	3,557	3,094
San Juan Lajarcia	161	674	19
San Pedro Mártir Quiechapa	64	722	36
Santa Ana Tavela	82	1,012	6
Santa Catalina Quieri	47	992	896
Santa Catarina Quioquitani	46	439	369
Santa María Ecatepec	720	4,253	515
Santa María Quiegolani	122	1,537	1,240