Brisbane spent the entire 2000 NRL season from round four in first position on the ladder. The Broncos started the season with an unbeaten run of 8 matches before going down to the Penrith Panthers in round 9. The Broncos were the first team to play the newly formed Wests Tigers (Merged team of Balmain Tigers and Western Suburbs Magpies) with both teams sharing the points with a 24-24 draw.
The Broncos went on a Win–loss run for 8 rounds before winning 7 of their last 8 regular season matches to finish Minor Premiers. Also the Broncos suffered their worst collapse in the club history when they led 22-4 at halftime to lose 26-22 against the Newcastle Knights in round 18.
The Qualifying Final was a different story when the Broncos came from 20-6 down at halftime to win 34-20 against the 8th-placed Cronulla Sharks. The Broncos had a week off to prepare for the Parramatta Eels in the Preliminary Final which the Broncos won 16-10 to go into a Grand Final against the Sydney Roosters. From the 10th minute, the Broncos led all the way when Michael De Vere landed a penalty goal to give the Broncos a 2-0 lead, erasing a 0 deficit in round 26 against Sydney when Sydney beat Brisbane 28-0. Broncos led at halftime 10-2 at halftime to go out winners 14-6 to clinch their 5th premiership in 9 years.