Availles-Limouzine (French pronunciation: [avaj limuzin]; Occitan: Avalha Lemosina) is a commune in the west-central department of Vienne, in Nouvelle-Aquitaine.

The river Clouère flows north-westward through the western part of the commune, then forms its northwestern border. The river Vienne forms part of the commune's south-eastern border, then flows northward through the commune; the town lies on its left bank.