U.S. Highway 6 (US-6) in the U.S. state of Nebraska is a United States Numbered Highway which goes from the Colorado border west of Imperial in the west to the Iowa border in the east at Omaha. Significant portions of the highway are concurrent with other highways, most significantly, US-34 between Culbertson and Hastings. Also, from Milford east to the Iowa border, the highway is closely paralleled by Interstate 80 (I-80). Large portions of the route parallel the Chicago, Burlington and Quincy Railroad.

US-6 enters Nebraska from Colorado west of Imperial on a short southeasterly segment. It turns east and stays due east until shortly before Imperial. It then goes into Imperial and meets Nebraska Highway 61 (N-61). The two routes are paired together until they separate at the Enders Reservoir State Recreation Area. It goes in a generally southeasterly direction until it meets US-34 west of Culbertson.

US-6 and US-34 continue east together through Culbertson and at McCook, is briefly concurrent with US-83. US-6/US-34 continue together in a northeasterly direction through Cambridge, then turns due east and meets US-283 in Arapahoe. Near Edison, it meets US-136, which begins at its intersection with US-6/US-34. Further east, the two highways meet N-4 and turns northeast toward Holdrege. In Holdrege, US-6/US-34 meet US-183. The highways continue on a northeasterly trajectory through Minden until Heartwell. At Heartwell, US-6/US-34 turns due east until Hastings. In Hastings, US-6/US-34 meet US-281 and US-34 separates to go with US-281 while US-6 continues eastward.

US-6 continues on a due east highway from Hastings. Near Sutton, the highway turns northeast to go through Sutton. It continues east, and, at Fairmont, US-6 encounters US-81. After passing through Friend, US-6 meets N-15, and the two highways overlap until shortly before Milford. US-6 goes east, then north out of Milford, then US-6 turns east to go toward Lincoln.

In Lincoln, US-6 comes into the city on West "O" Street, portions of which are divided highway. At Sun Valley Boulevard, it turns to go northeasterly. At North 10th Street, US-6 turns north-northwest and becomes North 11th Street, a divided highway. At Cornhusker Highway, US-6 turns east with a short urban connection to I-180 on the west along Cornhusker. US-6 then follows Cornhusker Highway, which is a divided highway, northeast out of the city. At the eastern end of Cornhusker Highway (near Waverly), US-6 meets I-80.

From I-80, US-6 goes northeast through Waverly, Greenwood, and Ashland. East of Ashland, US-6 crosses the Platte River. After that, US-6 meets N-31 in Gretna, where US-6 turns north with N-31 on a divided highway. US-6/N-31 meet US-275 and N-92 near the Elkhorn neighborhood of Omaha, and they separate in Elkhorn itself at a freeway interchange which also has Nebraska Link 28B, a connector to US-275.

At this point, US-6 goes onto the freeway, the West Dodge Expressway, and turns due east to go toward Downtown Omaha. At 137th Street is the exit for Boys Town. Between 120th and 108th streets, US-6 is an elevated freeway with separate viaducts for eastbound and westbound traffic. Shortly after this ends, US-6 meets I-680. East of I-680, US-6 continues east as West Dodge Road and at Cass Street, turns briefly southeast where West Dodge Road ends, and follows Dodge Street eastward. Before North 30th Street, US-6 splits into two one-way streets, with Dodge Street serving westbound traffic, and Douglas Street serving the eastbound. US-6 goes through downtown and then goes up onto I-480, which is an elevated freeway around Downtown Omaha, and, shortly thereafter, crosses into Iowa via the Grenville Dodge Memorial Bridge.

When the U.S. Numbered Highway System was created in 1926, much of the current US-6 in Nebraska was US-38. The route was slightly different in the Omaha area, as it turned east from 204th Street onto Q Street to go through what was the city of Millard. It went through Millard on what is now Millard Avenue (N-50), then north on 132nd Street, then east on Center Street, and then north on 36th Street to end at Farnam Street. In 1932, US-38 was deleted and replaced by US-6.

The cities of Hastings and Lincoln also each had a US-6 City. These are former routes for US-6 in those cities. US-6 City in Hastings was deleted in 1970 and, in Lincoln, US-6 City was deleted in 1983.

The Nebraska Department of Roads is planning a total rebuild and partial realignment/rerouting of US-6 from its current path along Sun Valley Boulevard in Lincoln. The project is years away from being built.

• Grand Army of the Republic Highway (statewide)
• Carl T. Curtis Drive in Kearney County
• West "O" Street, Sun Valley Boulevard, North 11th Street, Cornhusker Highway in Lincoln
• 204th Street, West Dodge Expressway, West Dodge Road, Dodge Street, Douglas Street, Gerald R. Ford Expressway in Omaha

All exits are unnumbered.

County	Location	mi	km	Destinations	Notes
Chase	​	0.000	0.000	US 6 west – Holyoke, Sterling	Continuation into Colorado
	Imperial	24.11	38.80	S-15A south (Broadway Street)
		24.95	40.15	N-61 north	Western end of N-61 overlap
	Enders	34.53	55.57	N-61 south	Eastern end of N-61 overlap
Hayes	Hamlet	49.70	79.98	S-43A north
Hitchcock	Palisade	57.21	92.07	N-25A north – Hayes Center
	​	63.36	101.97	N-25 – Hayes Center, Trenton
	​	70.54	113.52	L-44C east
	​	71.11	114.44	US 34 west	Western end of US 34 overlap
	​	71.52	115.10	L-44C west
	Culbertson	74.03	119.14	N-17 south
Red Willow	McCook	84.78	136.44	US 83 north	Western end of US 83 overlap
		86.21	138.74	US 83 south (6th Street)	Eastern end of US 83 overlap
Furnas	Cambridge	111.38	179.25	N-47 south (Patterson Street)
	Arapahoe	125.86	202.55	US 283 (Nebraska Avenue)
	​	132.06	212.53	US 136 east
	​	139.99	225.29	N-46 south
Harlan	​	144.46	232.49	N-4 east
Phelps	Holdrege	157.16	252.92	N-23 west (4th Avenue)
		157.76	253.89	US 183 (Burlington Street)
Kearney	Axtell	169.60	272.94	N-44 south (21 Road)	Western end of N-44 overlap
		173.68	279.51	N-44 north (25 Road)	Eastern end of N-44 overlap
	Minden	180.78	290.94	N-10
	​	181.78	292.55	Truck Route to N-74 east
Adams	Kenesaw	197.40	317.68	S-1A north (Smith Way)
	Juniata	205.38	330.53	S-1B north (Juniata Avenue)
	Hastings	208.88	336.16	S-1C north
		210.87	339.36	US 281 south (Baltimore Avenue) – Red Cloud	Western end of US 281 overlap
		211.41	340.23	US 34 east / US 281 north (Burlington Avenue) to I-80 – Hastings Museum	Eastern end of US 34/US 281 overlap; serves Mary Lanning Healthcare
	​	214.28	344.85	Showboat Boulevard (County Truck Route) to I-80 / US 34 north / US 281 north
Clay	Harvard	227.15	365.56	S-18A north (Road K)
	​	230.17	370.42	N-14 south (Road N)	Western end of N-14 overlap
	​	233.14	375.20	N-14 north (Road Q)	Eastern end of N-14 overlap
	Saronville	236.14	380.03	S-18G north (Road T)
Fillmore	Fairmont	255.63– 255.65	411.40– 411.43	US 81 – York, Geneva	Interchange
Saline	Cordova	268.79	432.58	S-76A north
	Friend	271.79	437.40	L-80E
	​	277.78	447.04	N-15 south	Western end of N-15 overlap
	Dorchester	278.39	448.03	N-33 east
		280.98	452.19	L-76E south
Seward	​	289.50	465.91	N-15 north	Eastern end of N-15 overlap
	​	295.48	475.53	L-80H north
	​	301.51	485.23	N-103
Lancaster	Emerald	306.49	493.25	S-55A south (SW 84th Street)
	Lincoln	308.96	497.22	L-55K north (NW 48th Street) to I-80 – Lincoln Air Park
		309.85– 310.47	498.66– 499.65	I-80 west	Closed; former exit 396 on I-80
		310.68– 310.69	499.99– 500.01	US 77 (Homestead Expressway) / I-80 east	Interchange
		314.32	505.85	To I-180 / US 34 / Cornhusker Highway / 11th Street
		314.50	506.14	14th Street / Antelope Valley Parkway	Interchange; no westbound exit (westbound access via Adams St or Yolande Ave)
		318.09	511.92	L-55X north (56th Street)	Former US 77 north
		319.80	514.67	70th Street south	Interchange; westbound exit and eastbound entrance via Cotner Boulevard
	Waverly	322.69– 323.27	519.32– 520.25	I-80 – Omaha	I-80 exit 409
Cass	​	335.61	540.11	N-63 south to I-80
Saunders	Ashland	337.44	543.06	N-66
Platte River		340.22	547.53	Bridge
Sarpy	Gretna	344.88	555.03	N-31 south (216th Street)	Western end of N-31 overlap
		348.46	560.79	N-370 east (West Gruenther Road)
Douglas	​	354.53	570.56	US 275 / N-92 (West Center Road)	Interchange
	Omaha	356.53	573.78	N-31 north (204th Street) / L-28B west (West Dodge Expressway west) – Fremont, Wahoo	Eastern end of N-31 overlap; western end of freeway section; L-28B is former US 275 Conn., previously US 30A west
		357.52	575.37	192nd Street
		358.52	576.98	180th Street
		359.41	578.41	168th Street
		360.51	580.18	156th Street
		361.00	580.97	150th Street / Applied Parkway	Applied Pkwy. not signed westbound
		361.50	581.78	144th Street
		361.97	582.53	137th Street – Boys Town
		362.50	583.39	132nd Street
		363.20– 363.23	584.51– 584.56	120th Street / 114th Street – Old Mill
		364.23– 365.12	586.17– 587.60	I-680 to I-80	I-680 exit 3
		365.29– 365.33	587.88– 587.94	102nd Street / 98th Street / Regency Parkway – Westroads Mall	98th St. not signed eastbound
		365.57	588.33	96th Street	At-grade intersection; eastern end of freeway section
		366.02	589.05	90th Street (N-133 north)	Southern terminus of N-133
		369.84	595.20	Saddle Creek Road	Interchange; bridge over Saddle Creek Underpass; former N-38
		371.27	597.50	I-480 east (Gerald R. Ford Expressway) / US 75 north (North Freeway)	Interchange; I-480/US 75 exits 2A-B
		372.80	599.96	To 9th Street	Interchange; eastbound left exit only
				The Riverfront	Interchange; eastbound exit only
		372.88	600.09	I-480 west (Gerald R. Ford Expressway east) to I-80	Western end of I-480 overlap; westbound left exit and eastbound left entrance; I-480 exit 4
Missouri River		373.00	600.29	Grenville Dodge Memorial Bridge; Nebraska–Iowa line
				I-480 east / US 6 east / Lincoln Highway Heritage Byway – Council Bluffs	Continuation into Iowa
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Closed/former       Concurrency terminus       Incomplete access       Route transition

• Dodge Street
• Lincoln Highway (Omaha)
• Saddle Creek Underpass

• The Nebraska Highways Page: Highways 1 to 30
• Nebraska Roads: US 6-38

U.S. Route 6
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