Heraclea Cybistra (Ancient Greek: Ἡράκλεια Κύβιστρα), or simply Heraclea or Herakleia (Ἡράκλεια), also transliterated as Heracleia, was a town of ancient Cappadocia or Cilicia; located at the site of modern Ereğli in Konya Province, Turkey.

In the Hittite Old Kingdom, it was known as Hupisna/Hubisna.

In the Hittite New Kingdom (Hittite Empire), Hupisna was part of the empire.

Dated to the 8th century BC, about 12 km south of Heraclea, is the Hittite İvriz relief.

It had some importance in Hellenistic times owing to its position near the point where the road to the Cilician Gates enters the hills. It lay in the way of armies and was more than once sacked by the Arab invaders of Asia Minor (by Harun al-Rashid in 806 and al-Ma'mun in 832). Heraclea was also the site of multiple battles in the Crusade of 1101, wherein Seljuk forces dealt a decisive blow to multiple contingents of the Crusader armies.

• List of ancient Greek cities
• Cybistra

•  This article incorporates text from a publication now in the public domain: Hogarth, David George (1911). "Heraclea s.v. Heraclea Cybistra". In Chisholm, Hugh (ed.). Encyclopædia Britannica. Vol. 13 (11th ed.). Cambridge University Press. p. 308.