Perperene (Ancient Greek: Περπερηνή Perperini) or Perperena (Περπερήνα Perperina) was a city of ancient Mysia on the south-east of Adramyttium, in the neighbourhood of which there were copper mines and good vineyards. It was said by some to be the place in which Thucydides had died. Stephanus of Byzantium calls the town Parparum or Parparon (Παρπάρων), but he writes that some called the place Perine. Ptolemy calls it Perpere or Permere. According to the Suda, Hellanicus of Lesbos, a 5th-century BC Greek logographer, died at Perperene at age 85. At a later date it was given the name Theodosiopolis or Theodosioupolis (Θεοδοσιούπολις).

It is located near Aşagı Beyköy, on the Kozak plateau near Bergama in the İzmir Province of Turkey in western Anatolia.

Perperene was the seat of a bishop; no longer a residential bishopric, it remains a titular see of the Roman Catholic Church.

 This article incorporates text from a publication now in the public domain: Smith, William, ed. (1854–1857). "Perperena". Dictionary of Greek and Roman Geography. London: John Murray.

• [1], Ancient coins of Perperene

39°15′37″N 26°57′47″E / 39.2602°N 26.963°E / 39.2602; 26.963