Nebraska Highway 41 is a highway in Nebraska. It runs for a length of 103.53 miles (166.62 km) in a west-to-east direction. Its western terminus is in Clay Center at an intersection with Nebraska Highway 14 and Nebraska Spur 18D. Its eastern terminus is at an intersection with Nebraska Highway 50 north of Tecumseh.

Nebraska Highway 41 begins in Clay Center at an intersection with Nebraska Highway 14 and Nebraska Spur 18D. It goes east out of Clay Center into farmland until Geneva. In Geneva, it runs on an old alignment of U.S. Highway 81. It meets US 81 just east of Geneva and continues east until meeting Nebraska Highway 15. The two highways overlap for 2 miles (3.2 km). It turns east and at Wilber, meets Nebraska Highway 103. It continues east through Clatonia and briefly overlaps U.S. Highway 77. It continues east and meets Nebraska Highway 43 at Adams. Highway 41 continues east until Sterling, where it then angles southeasterly until St. Mary. After St. Mary, the highway turns straight east again and ends at Nebraska Highway 50 north of Tecumseh.

County	Location	mi	km	Destinations	Notes
Clay	Clay Center	0.00	0.00	N-14 (Center Street) / S-18D west (West Johnson Street)	Western terminus
Fillmore	Geneva	25.02	40.27	US 81
	Milligan	35.83	57.66	S-30H south
Saline	​	46.82	75.35	N-15 north (County Road 1100)	West end of N-15 overlap
	​	48.83	78.58	N-15 south (County Road 1100)	East end of N-15 overlap
	Swanton	53.83	86.63	S-76D south (County Road 1600)
	Wilber	60.37	97.16	N-103 (South Main Street)
Gage	​	73.04	117.55	US 77 south (Southwest 14th Road)	West end of US 77 overlap
	​	74.54	119.96	US 77 north (South 12th Road)	East end of US 77 overlap
	Firth	79.83	128.47	S-34B north (South 82nd Road)
	Adams	85.11	136.97	S-34C south
		85.55	137.68	N-43 north
Johnson	​	103.57	166.68	N-50	Eastern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• Nebraska Roads: NE 41-60