I-15 and SR 15 are part of the California Freeway and Expressway System, and are part of the National Highway System, a network of highways that are considered essential to the country's economy, defense, and mobility by the Federal Highway Administration. I-15 from SR 76 to SR 91 and SR 58 to SR 127 is eligible to be included in the State Scenic Highway System, but it is not officially designated as a scenic highway by the California Department of Transportation.

SR 15 begins south of I-5 at 32nd Street near Harbor Drive. After this, SR 15 has an interchange with SR 94, which has been cited as not being up to Interstate standards. The route then meets I-805; however, one can only continue in the same direction that they were going at this interchange, since the overall shape of this interchange is an elongated "X". Between the Polk Avenue and Orange Avenue overpasses, the freeway goes under a city park that was built on top of the freeway during construction in 2001. Pedestrian bridges were also built at Monroe Avenue and Landis Street to reduce the effects of the freeway geographically dividing the community. Between I-805 and I-8, SR 15 follows the former alignment of 40th Street, which was its former routing as a city street. It continues seamlessly into the southern terminus of I-15 at I-8; on the northbound conversion to I-15 at I-8, there is no "End SR 15" sign.

There are various local names for the highway, such as the Escondido Freeway between San Diego and Escondido. I-15 between SR 163 and Pomerado Road / Miramar Road is known as the Semper Fi Highway in recognition of the nearby Marine Corps Air Station Miramar. I-15 between Scripps Poway Parkway and Camino Del Norte is known as the Tony Gwynn Memorial Freeway in recognition of Tony Gwynn, who played baseball for the San Diego Padres and San Diego State. North of the Escondido city limits, it is known as the Avocado Highway, whose designation ends upon entering Temecula. There are other local names as noted below.

Heading northward, I-15 currently begins at I-8, at the same place that its continuation, SR 15, begins its southward journey. I-15 goes through Mission Valley and Kearny Mesa, intersecting with SR 52 just before merging with SR 163. After traversing the Marine Corps Air Station Miramar, I-15 comes into Rancho Peñasquitos, where it meets the eastern end of SR 56. Northward, the route crosses Lake Hodges inside the upper San Diego city limits. I-15 continues north into Escondido, where it intersects with SR 78.

North of Escondido, I-15 goes through hilly terrain and farmland, passes under the Lilac Road Bridge and approaches the community of Fallbrook near the SR 76 interchange. It passes the community of Rainbow, crosses the Riverside county line and descends into the Inland Empire.

In Temecula, I-15 runs concurrently with SR 79 for 3.2 miles (5 km) before the latter branches off toward Hemet. In Murrieta, I-15 splits from its only auxiliary route in California, I-215, which retains the Escondido Freeway designation and runs through the two largest cities in the Inland Empire, Riverside and San Bernardino. I-15 continues northwest as the Temecula Valley Freeway.

I-15 runs along the eastern edge of the Santa Ana Mountains, passing through the cities of Wildomar and Lake Elsinore. In Lake Elsinore, I-15 intersects SR 74, a major highway connecting the city with San Juan Capistrano as well as points east such as Perris, Hemet, Idyllwild, and the Coachella Valley. It continues northwest through the unincorporated area of Temescal Valley as the Corona Freeway and passes through the city of Corona. During this stretch, I-15 has an interchange with SR 91, a major east–west highway; this interchange serves as a vital link between southwestern Riverside County and Orange County. North of SR 91, I-15 continues through the city of Norco, crosses the Santa Ana River, and heads due north along the boundary between the cities of Eastvale and Jurupa Valley. I-15 enters San Bernardino County just past an interchange with SR 60, another major east–west highway, which connects I-15 with the Chino Valley and the southern San Gabriel Valley. I-15 passes through the city of Ontario on its way to I-10, the main east–west artery though Southern California. North of I-10, I-15 passes through the cities of Rancho Cucamonga and Fontana as it intersects SR 210, an east–west highway skirting the San Gabriel and San Bernardino mountain ranges. SR 210 connects I-15 to major foothill communities such as Pasadena, Rialto, and San Bernardino. I-15 also crosses old US 66 during this stretch of highway, which is signed as SR 66, Foothill Boulevard. At this junction, I-15 takes a strongly northeastern alignment as it moves to rejoin with its spur route, I-215, in Devore, in northern San Bernardino. The highway then heads northward and upward through the Cajon Pass, an important mountain pass that is the primary route between Southern California and points further north and east.

The portion of I-15 that is located between its northern and southern junctions with I-215 is also used by many local residents as the major north–south route for the western portions of the San Bernardino–Riverside–Ontario metropolitan area. (I-215 serves a similar function in the eastern portion of the metropolitan area. These two highways are also the only continuous north–south freeways in the area.)

North of Limonite Avenue (south of SR 60), I-15 is known as the Ontario Freeway (formerly known as the Devore Freeway prior to 1989). After its northern merge with I-215 in Devore, I-15 is called the Barstow Freeway or the Mojave Freeway. A short section between SR 138 and Oak Hill Road is also designated as the CHP Officer Larry L. Wetterling and San Bernardino County Sheriff's Lieutenant Alfred E. Stewart Memorial Highway, named after two officers killed in the line of duty. On this stretch of highway, I-15 northbound splits from I-15 southbound, where the road ascends up a steep grade until it reaches Cajon Summit (elevation 4,260 feet (1,300 m)) just south of the High Desert communities of Hesperia and Oak Hills. Tractor-trailer trucks headed southbound are required to travel at the posted speed limit of 45 mph (72 km/h) or less due to the steep downward grade. The southbound lanes provide a runaway truck ramp as a safety feature. The two halves of the highway rejoin shortly before reaching Cajon Summit.

North of the Cajon Pass, I-15 traverses the High Desert cities of Hesperia, where it meets the southern end of US 395, and Victorville. I-15 passes through desert for 25 miles (40 km) before reaching Barstow, where it meets the eastern terminus of SR 58 and the western terminus of I-40. It then passes Zzyzx Road more than 50 miles (80 km) later, before reaching the town of Baker. The sign for Zzyzx Road—alphabetically the last place name in the world—is a landmark of sorts on the drive between Los Angeles and Las Vegas. Northeast of Baker, I-15 passes through the Halloran Summit near Halloran Springs at an elevation of over 4,000 feet (1,200 m), then descends into the Shadow Valley before ascending again through the Mountain Pass at an elevation of 4,730 feet (1,440 m). A runaway truck ramp is provided for northbound I-15 traffic near the dry Ivanpah Lake at the end of Mountain Pass. I-15 then crosses the Nevada state line at the casino town of Primm, Nevada, 40 miles (64 km) southwest of Las Vegas.

The Mojave Freeway is fairly busy on weekdays, since it connects the rapidly growing exurbs of the Victor Valley with the Los Angeles area. On weekends and holidays, however, it can sometimes be jammed with Californians driving to Las Vegas for short vacations.

There are two sections of High-occupancy toll (HOT) lanes along I-15. The first section is in San Diego County between SR 163 in San Diego and SR 78 in Escondido. The lanes were originally constructed as reversible carpool lanes in 1988 before they were converted into express lanes a decade later. Between 2004 and 2008, construction extended the lanes north from SR 56 to Del Lago Boulevard in Escondido. Then, between 2009 and 2012, work was done to widen the southern reversible segment from two lanes to four, and then extend the corridor north to SR 78. The lanes, dubbed a "highway within a highway", include a movable "zipper" barrier for 16 miles (26 km), which can be changed to create an extra lane as demand allows. In addition, five direct access ramps allow for easier local access, as well as access to bus service from MTS Rapid.

The second segment of HOT lanes is in Riverside County, featuring one to two tolled express lanes in each direction from Cajalco Road in Corona to SR 60. These lanes began construction in 2018 and opened in 2021.

The HOT lanes in Riverside County, administered by the Riverside County Transportation Commission (RCTC), have different toll polices than the ones in San Diego County, administered by the San Diego Association of Governments (SANDAG). In both segments, solo drivers are tolled using a congestion pricing system based on the real-time levels of traffic. All tolls are collected using an open road tolling system, and therefore there are no toll booths to receive cash. For the segment in Riverside County, carpools with three or more people are not charged, provided they have a FasTrak Flex transponder with its switch set to indicate the number of the vehicle's occupants (1, 2, or 3 or more). Solo drivers and carpools with two people may also use the FasTrak standard tag without the switch. Drivers without any FasTrak tag on the Riverside County HOT lanes will be assessed a toll violation regardless of whether they qualified for free. For the segment in San Diego County, each solo driver is required to carry a FasTrak transponder, while carpools, vanpools, transit riders, clean air vehicles, and motorcycles are not charged. SANDAG does not offer the switchable FasTrak Flex tags directly, and instead instructs those drivers who do qualify for free to just remove their FasTrak standard tag off their windshield or cover it in the provided mylar bag to avoid being charged.

A separate project in San Bernardino County would extend the express lanes to Duncan Canyon Road in Fontana, and there are also long-range plans to extend the toll lanes at least as far south as SR 74 (Central Avenue) in Lake Elsinore.

I-15 replaced US 395 between San Diego and Temecula, US 66 between San Bernardino and Barstow, and US 91 north of Barstow.

I-15 was initially planned to run from I-10 near San Bernardino along the current I-215 alignment then up through the Cajon Pass and on to Las Vegas, with a distance of 186.24 miles (299.72 km) within the state. California successfully argued in favor of the addition south to San Diego, suggesting that the freeway would connect the major military bases, the former March AFB (now March ARB) and the former NAS Miramar (now MCAS Miramar). US 395 was then signed TEMP-15 and the "old" I-15 between Devore and San Bernardino became part of modern-day I-215.

On January 24, 1957, the State Highway Commission defined the Escondido Freeway as what are now Routes 15 and 215 from Route 805 to Route 91. This entire segment was previously US 395 when it was named. Since then, the definition was extended on Route 15 south to Route 8 by Assembly Concurrent Resolution 34, Chapter 67 in 1979. Meanwhile, the segment of Route 15 from the San Diego County Line to the I-15/I-215 interchange was named the Temecula Valley Freeway in 1990.

The original definition for the Corona Freeway, as named by the State Highway Commission on July 23, 1958, stated that it was "Routes 71, 91, and 15 from Route 10 West of Pomona to Route 215".

This legal definition has been amended twice: First, in 1990, the California Assembly passed Concurrent Resolution 125, Chapter 78, renaming I-15 between the San Diego County Line (which is further south from I-215) and Bundy Canyon Road near Lake Elsinore as the Temecula Valley Freeway.

Then, in 1993, the California Assembly passed legislation officially designating SR 71 as a part of the Chino Valley Freeway. However, the "Corona Freeway" name is sometimes still applied to this portion of SR 71; thus, despite the official change, guide signs on I-10 eastbound and SR 57 southbound at the Kellogg Interchange in Pomona continued to refer to SR 71 as the "Corona Freeway" until the signs were replaced some time later.

Present SR 15 was signed after the creation of I-15 in 1968. Since I-15's southern terminus was at I-8, SR 15 was signed mostly along 40th Street and Wabash Boulevard in San Diego to its merge with I-5. The portion between Adams Avenue and I-805 remained a city street for a long time, and this portion was not completed until January 2000. For this reason, the freeway is sometimes referred to as the 40th Street Freeway.

Before the completion of the freeway, from 1968 to 1992, the San Diego neighborhood was known for prostitution, drugs, driveby shootings, and gangs. This was indirectly caused by Caltrans' plans to build a freeway in this area on land where houses were. Because families did not want to live in these houses since they would be soon torn down, they rented them to individuals who were only going to be in the area on a temporary basis, many of whom were involved in illegal activities. Even though the freeway was officially added to the Caltrans proposals as early as 1968, it was not until March 1992 that construction began. Many in the city opposed the building of this freeway, although some petitioned for the freeway to be built because of the poor conditions in the neighborhood.

Most of I-15 has undergone major improvements from Devore to the Nevada State Line, beginning in 2002 and costing $349 million. These improvements were designed to improve traffic flow on the heavily traveled highway for those going to and from Las Vegas. Most of the construction was completed by winter 2009. Projects include adding 39 miles (63 km) of truck lanes on hills at various locations, repaving 76 miles (122 km) of I-15 at various locations, adding exit numbers, renovating and rehabilitating the rest area between Baker and the Nevada State Line (Valley Wells Rest Area), reconstructing bridges in Baker, and moving the agriculture inspection station from Yermo to the Nevada State Line and including a truck weigh station. The new agricultural inspection station opened in August 2018.

State Route 31
Location	Corona - Ontario
Existed	1934–1974

Interstate 15W
Location	Murrieta - Devore
Existed	1972–1974

In 1933, I-15 was defined as Legislative Route 193, running from pre-1964 Legislative Route 43 (present SR 91) in Corona to pre-1964 Legislative Route 9 (now SR 66), and was extended north to pre-1964 Legislative Route 31 (present I-15 and I-215) in 1935. The piece south of US 60 (Mission Boulevard), running along North Main Street, Hamner Avenue, and Milliken Avenue, was state-maintained by 1955, but was not assigned a signed number. This was still the only existing piece in 1963, and had a planned freeway replacement to the east.

In the 1964 renumbering, the route was assigned as SR 31. It was added to the Interstate Highway System in February 1972 as a realignment of I-15 (the former alignment became I-15E). However, as soon as the reroute was made, the cities of San Bernardino and Riverside voiced concerns that this new routing, which completely bypassed their city centers, would have a negative effect on their development plans. Together, these cities devised a plan in which the new western route via Corona and Ontario would become Interstate 15W, while US 395 would be renumbered Interstate 15E, regardless of the actual non-Interstate status of the latter route. Legislative changes were made in 1974, eliminating SR 31 (along with SR 71 south of Corona) in favor of I-15W. However, SR 31 continued to be signed—as temporary I-15W—until present I-15 was finished. (A 1986 map shows state maintenance continuing north past SR 60 to Jurupa Street, where it turned east to I-15.)

The segment signed as California SR 15 from I-5 to I-8 in San Diego is planned to be redesignated as part of I-15 once this segment is completely upgraded to Interstate standards, namely where the freeway's interchange with SR 94 is concerned. The interchange currently has left-exits and blind merges, and is due to be updated with a long-awaited widening of both SR 15 and SR 94. At that time, SR 15 is planned to be signed as part of I-15. The remaining portion of SR 15 conforms with Interstate standards.

In December 2018, the San Bernardino County Transportation Authority (SBCTA) approved the final environmental document for an 8-mile section of the San Bernardino County I-15 Express Lanes Project, spanning from Cantu-Galleano Ranch Road in Riverside County to Foothill Boulevard near Rancho Cucamonga. Construction on this section of express lanes is anticipated to begin in 2024.

In 2020, Brightline signed a 50-year lease for use of the I-15 right-of-way between the Victor Valley and Nevada border for use in their Brightline West high-speed rail service.

County	Location	mi	km	Exit	Destinations	Notes
San Diego	San Diego	0.00	0.00		32nd Street to Harbor Drive	At-grade intersection
		0.41	0.66	1A	Main Street	Southbound exit and northbound entrance; southern end of state maintenance
		0.55	0.89	1B-C	I-5 – National City, Chula Vista, Los Angeles	Southbound exit and northbound entrance; signed as exits 1B (north) and 1C (south); exit 13A on I-5
		0.77	1.24	1D	Ocean View Boulevard	Signed as exit 1 northbound
		1.07	1.72		Imperial Avenue	Exit removed in the late 1990s to conform SR 15 with federal highway minimum spacing requirements between adjacent interchanges
		1.85	2.98	2A	Market Street
		2.23	3.59	2B-C	SR 94 (M. L. King Jr. Freeway) / Home Avenue	Signed as exits 2B (east) and 2C (west) northbound; southbound exit to SR 94 east is via exit 3; exits 2A-C on SR 94
		3.37	5.42	3	I-805 north – Los Angeles	Northbound exit and southbound entrance; exit 14 on I-805
					I-805 south to SR 94 east	Southbound exit and northbound entrance; exit 14 on I-805
		4.67	7.52	5A	University Avenue – City Heights Transit Plaza
		5.05	8.13	5B	El Cajon Boulevard (Historic US 80) – Boulevard Transit Plaza	Former US 80
		5.61	9.03	6A	Adams Avenue
		6.13	9.87	6B	I-8 / Camino del Rio South – Beaches, El Centro	Northern end of SR 15; southern end of I-15; exits 7A-B on I-8
		6.82	10.98	7	Friars Road	Signed as exits 7A (east) and 7B (west) northbound
		8.37	13.47	8	Aero Drive
		9.25	14.89	9	Balboa Avenue / Tierrasanta Boulevard	Former eastern end of SR 274
		10.00	16.09	10	Clairemont Mesa Boulevard	Southbound exit is part of exit 11
		10.58	17.03	11	SR 52	Exit 7 on SR 52
				—	I-15 Express Lanes (San Diego County)	Southern end of Express Lanes
				—	SR 163 south	Express Lanes access only; southbound exit and northbound entrance
		12.13	19.52	12	SR 163 south (Cabrillo Freeway) – Downtown	Southbound exit and northbound entrance; former US 395 south
		13.34	21.47	13	Miramar Way	Serves Marine Corps Air Station Miramar
		14.29	23.00	14	Miramar Road / Pomerado Road	Former US 395 north
		15.01	24.16	15	Carroll Canyon Road
				—	Hillery Drive – Mira Mesa	Express Lanes access only
		15.93	25.64	16	Mira Mesa Boulevard
		17.32	27.87	17	Mercy Road / Scripps Poway Parkway
		17.82	28.68	Los Peñasquitos Creek Bridge
		18.18	29.26	18	Poway Road (CR S4) / Rancho Peñasquitos Boulevard
				—	SR 56 west / Ted Williams Parkway	Express Lanes access only; northbound exit and southbound entrance
				—	Sabre Springs-Peñasquitos Transit Station	Express Lanes access only
		19.48	31.35	19	SR 56 west (Ted Williams Freeway) / Ted Williams Parkway	Exit 9 on SR 56
		20.58	33.12	21	Carmel Mountain Road
		21.92	35.28	22	Camino del Norte
		22.94	36.92	23	Bernardo Center Drive
				—	George Cooke Express Drive – Rancho Bernardo	Express Lanes access only
		23.69	38.13	24	Rancho Bernardo Road
		26.03	41.89	26	Pomerado Road (CR S5) / West Bernardo Drive	Former US 395 south
		26.20	42.16	Lake Hodges Bridge
	Escondido	26.98	43.42	27	Via Rancho Parkway
				—	Del Lago Boulevard / Beethoven Drive	Express Lanes access only
		27.66	44.51	28	Centre City Parkway (I-15 Bus. north)	Northbound exit and southbound entrance; former US 395 north
		28.77	46.30	29	Felicita Road / Citracado Parkway
		30.10	48.44	30	9th Avenue / Auto Park Way
		30.63	49.29	31	Valley Parkway (CR S6) – Downtown Escondido
				—	Hale Avenue	Express Lanes access only; northbound exit and southbound entrance
				—	I-15 Express Lanes (San Diego County)	Northern end of Express Lanes
		31.52	50.73	32	SR 78 – Oceanside, Ramona	SR 78 exit 17 westbound, 17A-B eastbound
		32.87	52.90	33	El Norte Parkway
		33.92	54.59	34	Centre City Parkway (I-15 Bus. south) / Country Club Lane	Southbound exit and northbound entrance; former US 395 south
	​	36.64	58.97	37	Deer Springs Road (CR S12) / Mountain Meadow Road
	Bonsall	40.85	65.74	41	Gopher Canyon Road / Old Castle Road
		43.29	69.67	43	Old Highway 395	Former US 395
	​	46.49	74.82	46	SR 76 – Pala, Oceanside
	Fallbrook	50.59	81.42	51	Mission Road (CR S13) – Fallbrook
San Diego–Riverside county line	Rainbow	54.08	87.03	54	Rainbow Valley Boulevard
Riverside	Temecula	57.70	92.86	58	SR 79 south (Temecula Parkway) – Warner Springs, Indio	Southern end of SR 79 overlap; former SR 71 south
		59.25	95.35	59	Rancho California Road / Old Town Front Street
		60.88	97.98	61	SR 79 north (Winchester Road)	Northern end of SR 79 overlap
	Temecula–Murrieta line	61.68	99.26	62	French Valley Parkway	Southbound exit only
	Murrieta	63.00	101.39	63	I-215 north (Escondido Freeway north) – Riverside, San Bernardino	Northbound exit and southbound entrance; southbound access is via exit 64; former I-15E north / US 395 north
		63.73	102.56	64	Murrieta Hot Springs Road to I-215 north – Riverside	“To I-215” not signed northbound
		64.86	104.38	65	California Oaks Road / Kalmia Street
	Wildomar	67.90	109.27	68	Clinton Keith Road
		69.34	111.59	69	Wildomar Trail	Formerly Baxter Road
		70.56	113.56	71	Bundy Canyon Road
	Lake Elsinore	73.43	118.17	73	Diamond Drive / Railroad Canyon Road
		75.21	121.04	75	Main Street (I-15 Bus. north)
		76.54	123.18	77	SR 74 (Central Avenue) – San Juan Capistrano, Perris
		78.12	125.72	78	Nichols Road
		80.95	130.28	81	Lake Street (I-15 Bus. south)
	Temescal Valley	84.67	136.26	85	Indian Truck Trail
		87.54	140.88	88	Temescal Canyon Road	Former SR 71
	Corona	89.91	144.70	90	Weirick Road / Dos Lagos Drive
		91.08	146.58	91	Cajalco Road
				—	I-15 Riverside Express Lanes	Southern end of Express Lanes
		92.08	148.19	92	El Cerrito Road
		92.96	149.60	93	Ontario Avenue	Former SR 71
		94.62	152.28	95	Magnolia Avenue
				—	91 Express Lanes west	Express Lanes access only
		95.77	154.13	96	SR 91 (Riverside Freeway) – Riverside, Beach Cities	Signed as exits 96A (west) and 96B (east) southbound; former US 91; SR 91 exit 51
	Corona–Norco line	97.14	156.33	97	Hidden Valley Parkway	Formerly Yuma Drive
	Norco	97.90	157.55	98	Second Street (I-15 Bus. north)
		99.87	160.73	100	Sixth Street (I-15 Bus. south)
	Eastvale–Jurupa Valley line	102.53	165.01	103	Limonite Avenue
		104.62	168.37	105	Cantu-Galleano Ranch Road
				—	I-15 Riverside Express Lanes	Northern end of Express Lanes
		105.74	170.17	106	SR 60 (Pomona Freeway) – Los Angeles, Riverside	Signed as exits 106A (east) and 106B (west); SR 60 exit 41 eastbound, 41A westbound
San Bernardino	Ontario	107.56	173.10	108	Jurupa Street / Auto Center Drive	Former SR 31 south
		108.94	175.32	109	I-10 (San Bernardino Freeway) – Los Angeles, San Bernardino, Indio	Signed as exits 109A (west) and 109B (east) southbound; former US 99; I-10 exits 58A-B eastbound; 58 westbound
	Rancho Cucamonga	109.60	176.38	110	4th Street
		111.85	180.01	112	SR 66 (Foothill Boulevard)	Former US 66
	Rancho Cucamonga–Fontana line	113.26	182.27	113	Base Line Road
		114.64	184.50	115	SR 210 (Foothill Freeway) – Pasadena, San Bernardino, Redlands	Signed as exits 115A (east) and 115B (west) northbound, reverse southbound; exit 64A on SR 210; future I-210
	Fontana	116.20	187.01	116	Summit Avenue
		117.58	189.23	118	Duncan Canyon Road
	Fontana–Rialto line	119.39	192.14	119	Sierra Avenue
	​	122.20	196.66	122	Glen Helen Parkway
	San Bernardino	122.92	197.82	123	I-215 south (Barstow Freeway south) / Devore Road	Northbound signage; former I-15E / US 91 / US 395 south / US 66 west; I-215 exit 54B
				—	I-15 Truck north / Kenwood Avenue	South end of truck bypass
				123	I-215 south (Barstow Freeway south) – San Bernardino, Riverside	Southbound signage; former I-15E / US 91 / US 395 south / US 66 west; I-215 exit 54B
				—	I-15 Truck south	North end of truck bypass
		124.10	199.72	124	Kenwood Avenue	Southbound signage
	​	129.15	207.85	129	Cleghorn Road
	​	130.51	210.04	131	SR 138 – Palmdale, Silverwood Lake
	​	135.33	217.79	Cajon Summit, elevation 4,260 feet (1,300 m)
	Hesperia	137.76	221.70	138	Oak Hill Road
		139.53	224.55	140	Ranchero Road
		141.47	227.67	141	US 395 north – Bishop, Adelanto	Northbound exit and southbound entrance; southern end of US 395
					Joshua Street to US 395 north	Southbound exit and northbound entrance
		143.14	230.36	143	Main Street – Hesperia, Phelan
	Hesperia–Victorville line	146.73	236.14	147	Bear Valley Road – Lucerne Valley
	Victorville	147.96	238.12	148	La Mesa Road / Nisqualli Road
		149.65	240.84	150	SR 18 west (Palmdale Road / I-15 Bus. north)	Southern end of SR 18 overlap; former US 66 east / US 91 north
		150.57	242.32	151A	Roy Rogers Drive
		151.17	243.28	151B	Mojave Drive
		152.63	245.63	153A	SR 18 east (I-15 Bus. south / CR 66) – Victorville, Apple Valley	Northern end of SR 18 overlap; former US 66 / US 91
		152.71	245.76	153B	E Street	Northbound exit and entrance
		153.54	247.10	154	Stoddard Wells Road
	Apple Valley	156.65	252.10	157	Stoddard Wells Road – Bell Mountain
		161.25	259.51	161	Dale Evans Parkway – Apple Valley
	​	165.10	265.70	165	Wild Wash Road
	​	169.30	272.46	169	Hodge Road
	Barstow	174.98	281.60	175	Outlet Center Drive
		177.91	286.32	178	Lenwood Road
		179.25	288.47	179	SR 58 west – Bakersfield	SR 58 exit 234 eastbound to I-15 southbound
		180.76	290.91	181	L Street (I-15 BL east) / West Main Street (CR 66)
		182.69	294.01	183	SR 247 south (Barstow Road)
		183.56	295.41	184A	I-40 east – Needles	Northbound exit and southbound entrance; southbound access is via exit 184; western terminus of I-40
		184.09	296.26	184B	East Main Street (I-15 Bus. / CR 66) to I-40 – Needles	Signed as exit 184 southbound; former US 66
		186.03	299.39	186	Old Highway 58 west	Former US 91 south/US 466/SR 58 west
	​	188.74	303.75	189	Fort Irwin Road	Serves Fort Irwin
	​	190.98	307.35	191	Ghost Town Road	Serves the ghost town of Calico
	Yermo	193.78	311.86	194	Calico Road – Yermo
		195.52	314.66	196	Yermo Road – Yermo
	​	196.00– 196.50	315.43– 316.24	Agricultural Inspection Station (closed; was southbound only)
	​	197.63	318.05	198	Minneola Road
	​	205.55	330.80	206	Harvard Road
	​	212.78	342.44	213	Field Road
	​	216.76	348.84	Clyde V. Kane Rest Area (Exit 217)
	​	220.73	355.23	221	Afton Road
	​	229.57	369.46	230	Basin Road
	​	233.38	375.59	233	Rasor Road
	​	239.32	385.15	239	Zzyzx Road – Zzyzx
	Baker	244.95	394.21	245	Baker Boulevard (I-15 Bus. north) – Baker	Northbound exit and southbound entrance; former US 91 north / US 466 east
		245.72	395.45	246	SR 127 north / Kelbaker Road – Death Valley
		247.60	398.47	248	Baker Boulevard (I-15 Bus. south) – Baker	Southbound exit and northbound entrance; former US 91 south / US 466 west
	​	258.75	416.42	259	Halloran Springs Road
	​	264.71	426.01	265	Halloran Summit Road
	​	270.29	434.99	Valley Wells Rest Area (Exit 270)
	​	271.88	437.55	272	Cima Road
	​	280.61	451.60	281	Bailey Road
​	285.60	459.63	286	Nipton Road
​			Agricultural Inspection Station (southbound only); opened in 2018
​	290.54	467.58	291	Yates Well Road
​	295.37	475.35		I-15 north – Las Vegas	Continuation into Nevada
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Closed/former       Concurrency terminus       Electronic toll collection       Incomplete access       Route transition       Unopened

I-215 is the only auxiliary Interstate Highway associated with I-15 in California. It is a bypass of I-15, running between Murrieta and San Bernardino. I-215 connects the city centers of both Riverside and San Bernardino, while I-15 runs to the west through Corona and Ontario.

Business routes of Interstate 15 exist in Escondido, Lake Elsinore, Norco, Victorville, Barstow, and Baker.

• California Roads portal

Wikimedia Commons has media related to Interstate 15 in California.

• Caltrans: I-15 highway conditions
• Caltrans Traffic Conditions Map
• California Highway Patrol Traffic Incidents
• SANDAG FasTrak – includes toll information on the San Diego County Express Lanes and the other San Diego Area toll facilities
• Riverside County Express Lanes
• Interstate 15 @ Interstate-Guide.com

Interstate 15
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