The Diocese of San Jose, Nueva Ecija (Latin: Dioecesis Sancti Iosephi in Insulis Philippinis) is a Latin Church ecclesiastical territory or diocese of the Catholic Church in the Philippines.

The diocese was founded in 1984, having previously formed part of the Diocese of Cabanatuan. It is a suffragan of the Archdiocese of Lingayen-Dagupan.

The diocese held its first Diocesan Synod in March 2011 led by the Apostolic Nuncio to the Philippines. The diocese celebrated its Silver Anniversary of Canonical Erection last July 14, 2009. On April 20, Pope Benedict XVI named its third bishop, Mylo Hubert C. Vergara, as the bishop of Pasig. At present, the diocese is headed by its fourth bishop Roberto C. Mallari, former Auxiliary Bishop of the Archdiocese of San Fernando, Pampanga.

The Diocese of San Jose, Nueva Ecija, was created on Feb. 16, 1984 by Pope John Paul II and canonically erected on July 14, 1984. Its territory was taken from the Diocese of Cabanatuan which at same time of the division comprised the entire province of Nueva Ecija.

Sixteen parishes, out of forty one parishes of the Diocese of Cabanatuan were adjudicated to the Diocese of San Jose, Nueva Ecija. 80 percent of the people are Roman Catholics and the rest of 20 percent are members of different sects and denominations.

Bishop Florentino F. Cinense was appointed the diocese's first diocesan bishop on July 14, 1984. When appointed coadjutor bishop of Tarlac, he remained as apostolic administrator of San Jose, until the appointment of his successor Bishop Leo M. Drona on July 25, 1987. Bishop Leo M. Drona had been a Salesian of Don Bosco for twenty nine-years prior to his episcopal appointment. He is the first Filipino Salesian priest as well as the first Filipino Salesian bishop. In June 2004, Drona was transferred to the Diocese of San Pablo, Laguna as its third bishop. He was succeeded by Bishop Mylo Hubert C. Vergara, who was installed as the third bishop of the Diocese of San Jose de Nueva Ecija on May 14, 2005. Then Vergara transferred to the Diocese of Pasig. It was May 15 when Pope Benedict XVI named the current bishop, Roberto C. Mallari.

Bishop		Period in Office	Coat of Arms
1.	Florentino Ferrer Cinense, STL	May 24, 1984 - August 17, 1985 appointed Coadjutor Bishop of Tarlac
2.	Leo Murphy Drona, SDB	June 10, 1987 - May 14, 2004 appointed Bishop of San Pablo
3.	Mylo Hubert C. Vergara, SThD	February 12, 2005 - June 23, 2011 appointed Bishop of Pasig
4.	Roberto C. Mallari, SSS	July 10, 2012 - present

• Vicar General: Getty A. Ferrer
• Chancellor: Rufo Ramil H. Cruz
• Vice Chancellor: Vic Kevin O. Ferrer
• Oeconomous: Nestor E. Romano
• Judicial Vicar: Getty A. Ferrer

• Our Lady of the Sacred Heart College, Guimba
• St. Joseph School, San Jose City
• St. Pius X Institute, Cuyapo
• St. Pius X Institute of Nampicuan, Nampicuan
• Sacred Heart Academy, Lupao
• St. Andrew School, Pantabangan
• Holy Family Academy, Quezon
• Dominican High School, Santo Domingo
• Liceo de Christ the King, Talugtug
• St. Nicholas Academy, Carranglan

• San Sebastian School, Muñoz

• Don Bosco Training Center, Malasin, San Jose City

• Catholic Church in the Philippines
• List of Catholic dioceses in the Philippines