Muñoz, officially the Science City of Muñoz (Filipino: Lungsod Agham ng Muñoz, Ilocano: Siudad ti Siensia ti Muñoz), is a 4th class component city in the province of Nueva Ecija, Philippines. According to the 2020 census, it has a population of 84,308 people.

It is situated 30 kilometres (19 mi) from Cabanatuan, 44 kilometres (27 mi) from Palayan, and 146 kilometres (91 mi) north of the capital Manila. Due to its rich topography and tropical climate, it is now home to agricultural research and technology centers, committed to the production of information and technological breakthroughs to promote rural development, productivity and food security.

From its lowly origins as “Sitio Papaya”, it was renamed as Muñoz in 1886 in honor of Spanish Governor Don Francisco Muñoz. It was in 1913, under Executive Order No. 72, when Muñoz was declared as a new and independent municipality. By the virtue of Republic Act 8977 signed on November 7, 2000, Muñoz formally elevated to a city and country's only city with "Science" in its formal name.

The town got its name in honor of Don Francisco Muñoz, being the alcalde mayor and gobernadorcillo.

The Science City title was because of the presence of many state universities and colleges in the city, alongside many technological, vocational and industrial structures sprung up in the city.

In 1886, Papaya was changed into 'Muñoz' to honor Don Francisco Muñoz, the province's alcalde mayor, and the community's first appointed gobernadorcillo. Muñoz was annexed as a barrio of San Juan de Guimba municipality. Settlers trickled in from Bulacan and the Ilocos Region, with Pangasinenses & Kapampangans. In 1911, Factoria (now San Isidro town), the provincial capital, was totally flooded. Muñoz was then considered a possible new capital of the province.

At about the same time, the people of Barrios Muñoz and San Antonio, also in San Juan de Guimba town, and Palusapis in Santo Domingo municipality, together with Sitios Kabisukulan, Rang-ayan, Mataas na Lupa, Siniguelas, Purok Agrikultura, and Pulong Maragul in Talavera town, were organizing themselves to be separated from their three respective municipalities to become a new independent municipality. They were prepared to construct a municipal hall and a school building for the emerging town.

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On the recommendation of the Provincial Board of Nueva Ecija, then headed by Governor Isauro Gabaldon, and with approval of then Acting Governor General Newton Gilbert, the organized barrios and sitios were granted independence as a regular municipality on January 10, 1913, under the name of Muñoz. The seat of the fledgling municipal government was positioned in erstwhile Barrio Muñoz. The municipality of Muñoz was born and steadily grew to become an agricultural Science City in the making.

A municipal hall, a church, and a small public market were erected in Lumang Bayan (now Poblacion North). A road linking the young Muñoz town with the national highway from Barangay Bacal, Talavera was constructed. In World War II, Muñoz was the last stronghold of the Japanese Imperial Army; the Allied liberation in Muñoz by the joint United States and Philippine Commonwealth forces offensive razed the town to the ground in a matter of days.

In 2000, after achieving cityhood status, universities and scientific research institutes sprung up. The local government adopted and later ratified the Science city moniker.

Science City of Muñoz is politically subdivided into 37 barangays. Each barangay consists of puroks and some have sitios.

PSGC	Barangay	Population			±% p.a.
		2020		2010
03-49-17-001	Bagong Sikat	2.4%	2,031	2,033	▾	−0.01%
03-49-17-002	Balante	2.2%	1,865	2,039	▾	−0.89%
03-49-17-003	Bantug	13.2%	11,104	10,345	▴	0.71%
03-49-17-004	Bical	3.4%	2,868	2,793	▴	0.27%
03-49-17-005	Cabisuculan	1.5%	1,259	1,264	▾	−0.04%
03-49-17-006	Calabalabaan	1.4%	1,170	1,080	▴	0.80%
03-49-17-007	Calisitan	1.2%	1,009	968	▴	0.42%
03-49-17-008	Catalanacan	4.5%	3,783	3,200	▴	1.69%
03-49-17-009	Curva	1.5%	1,305	1,201	▴	0.83%
03-49-17-010	Franza	3.3%	2,822	2,650	▴	0.63%
03-49-17-011	Gabaldon	2.7%	2,309	2,118	▴	0.87%
03-49-17-012	Labney	1.3%	1,064	940	▴	1.25%
03-49-17-013	Licaong	1.8%	1,521	1,613	▾	−0.59%
03-49-17-014	Linglingay	3.7%	3,151	2,985	▴	0.54%
03-49-17-015	Mangandingay	2.2%	1,819	1,688	▴	0.75%
03-49-17-016	Magtanggol	2.9%	2,452	2,205	▴	1.07%
03-49-17-017	Maligaya	5.5%	4,656	4,643	▴	0.03%
03-49-17-018	Mapangpang	0.7%	627	575	▴	0.87%
03-49-17-019	Maragol	2.9%	2,458	2,935	▾	−1.76%
03-49-17-020	Matingkis	1.3%	1,093	972	▴	1.18%
03-49-17-021	Naglabrahan	0.7%	584	586	▾	−0.03%
03-49-17-022	Palusapis	3.5%	2,987	2,777	▴	0.73%
03-49-17-023	Pandalla	1.2%	990	963	▴	0.28%
03-49-17-024	Poblacion East	2.4%	2,006	2,080	▾	−0.36%
03-49-17-025	Poblacion North	3.2%	2,707	2,758	▾	−0.19%
03-49-17-026	Poblacion South	2.1%	1,790	2,350	▾	−2.68%
03-49-17-027	Poblacion West	3.9%	3,247	4,085	▾	−2.27%
03-49-17-028	Rang-ayan	2.7%	2,311	2,139	▴	0.78%
03-49-17-029	Rizal	2.1%	1,751	1,640	▴	0.66%
03-49-17-030	San Andres	2.1%	1,798	1,667	▴	0.76%
03-49-17-031	San Antonio	2.7%	2,305	2,166	▴	0.62%
03-49-17-032	San Felipe	2.4%	2,020	1,973	▴	0.24%
03-49-17-033	Sapang Cawayan	1.9%	1,570	1,483	▴	0.57%
03-49-17-034	Villa Isla	3.2%	2,686	2,811	▾	−0.45%
03-49-17-035	Villa Nati	2.8%	2,377	1,301	▴	6.21%
03-49-17-036	Villa Santos	1.2%	986	959	▴	0.28%
03-49-17-037	Villa Cuizon	2.2%	1,827	1,498	▴	2.00%
	Total		84,308	81,483	▴	0.34%

The National Government has an ongoing move to transfer the Talavera barangays of Matingkis (Talavera), Bakal 1, Bakal 2 and Bakal 3 to become part of Science City of Munoz for the reason that the said barangays are geographically and strategically within the said city. This was favored by most of the residents of the said barangays but opposed by the Municipal Government of Talavera.

Also there is a proposed separation of Villa Pinili (Bantug West) and San Juan (CLSU) which will include PNR (CLSU), and Sawmill (CLSU) from Barangay Bantug into two independent separate barangay.

Population census of Muñoz

Year	Pop.	±% p.a.
1918	11,333	—
1939	21,814	+3.17%
1948	21,748	−0.03%
1960	27,622	+2.01%
1970	35,723	+2.60%
1975	38,619	+1.58%
1980	43,211	+2.27%
1990	50,356	+1.54%
1995	60,162	+3.39%
2000	65,586	+1.87%
2007	71,669	+1.23%
2010	75,462	+1.89%
2015	81,483	+1.47%
2020	84,308	+0.67%
Source: Philippine Statistics Authority

Churches:

• The Church of Jesus Christ and Latter Day Saints
• Sacred Heart of Jesus Shrine
• San Sebastian parish Church
• Christ the Worker Parish Church
• Iglesia ni Cristo
• Christian Churches
• IIJMS Temples
• United Pentecostal Church
• The Apostolic Faith Church (Mission of Portland Oregon Inc.)
• Jesus Christ the Living God Fellowship (Conservative Baptist)
• Munoz Christian Church (FIFCOP)
• Lakas Angkan Ministry
• Muñoz Church of Christ

There are many new establishments in Munoz in the past few years. Notable are Jollibee Munoz, Mang Inasal Munoz, 7/11, BDO, Land Bank, Novo, Lucky 99, Friendship Supermarket, Inc (FSi), and the Villa-Mendoza Training Institute, are now major landmarks on the city.

In terms of commercial and shopping sector, Robinsons, Savemore and Puregold has also initially identified locations in the city for future construction. Fast-food chain operator Jollibee already established their store in the city.

With a bustling market center with rice trading as a major economic activity, it has transformed into its present status as a Science City by virtue of Republic Act 8977 on December 9, 2000. Being a science city, Muñoz was acknowledged as one of the members of League of Cities of the Philippines and became a pilot city of achieving the United Nation's Millennium Development Goals.

Research and development centers

• The Philippine Rice Research Institute (PhilRice) (formerly the Maligaya Rice Research and Training Center (MRRTC)) is found in Muñoz
• Central Office and National Genepool of the Philippine Carabao Center (PCC).
• National Freshwater and Fisheries Training and Research Center (NFFTRC)
• The main offices of the Bureau of Postharvest Research and Extension (BPRE) now known as Philippine Center for Postharvest Development and Mechanization (PhilMech)
• Bureau of Fisheries and Aquatic Resources (BFAR-NFFTC) are also based in Muñoz.

Members of the Muñoz City Council
(2022–2025)

Position	Name
District Representative (2nd Legislative District of the Province of Nueva Ecija)	Joseph Gilbert Violago
Chief Executive of the City Muñoz	Mayor Baby Armi L. Alvarez
Presiding Officer of the City Council of Muñoz	Vice Mayor Nestor L. Alvarez
Members of the City Council	Jose A. Ruiz Jr.
	Romeo A. Ruiz
	Jerry S. Fulgencio
	Allan S. Pingol
	Henry G. Agaloos
	Rommel Abon
	Altreb S. Castañeda
	Herminio F. Salcedo
	Vincent DV. Alvarez
	Edmond Balmeo

As with most towns in Central Luzon, inter-city transport is through the Pan-Philippine Highway (also known as Maharlika Highway/ Asian Highway 26), the country's principal transport backbone. The principal mode of transport is through Jeepneys with fixed routes, or through tricycles, whom you need to tell where to go.

Buses from Cagayan Valley to Manila and vice versa stops here.

From Manila, you can ride a public bus going to San Jose City, Nueva Ecija or take the North Luzon Expressway (NLEX) and Subic-Clark-Tarlac Expressway (SCTEX) and take La Paz Exit. And continue until reaching the city. You can also ride a public bus plying Cagayan Valley which exits at TPLEX (Tarlac–Pangasinan–La Union Expressway) Pura Exit; they continue to traverse through N114 (Pangasinan–Nueva Ecija Road) up to Baloc, Santo Domingo; and they turn left going to AH26 until you reach Muñoz.

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Land use	Hectares
Agricultural	9,819
Residential	2,847
Commercial and industrial	784
Institutional	740
Forest hills and pasture	1,215
Roads	246
Water bodies	516
Open spaces	138
Total	16,305

• Central Luzon State University - a state university located on a 658-hectare campus in the Science City of Muñoz, Nueva Ecija, Philippines. It serves as the lead agency of the Muñoz Science Community and hosts the Regional Research and Development Center in Central Luzon. CLSU is recognized for its significant contributions to agricultural research in Southeast Asia, particularly in areas such as aquatic culture (notably in the sex reversal of tilapia), ruminant studies, crop science, orchard management, and water management.

• Alexis Belonio - Filipino inventor
• Darren Espanto - Filipino Singer and Artist

• Official website
• Philippine Standard Geographic Code
• Philippine Census Information
• Local Governance Performance Management System